Syntheses of the marine alkaloids 6-oxofascaplysin, fascaplysin and their derivatives

Autor:	Alexandra S. Kuzmich, Maxim E. Zhidkov, Alexey Kantemirov, Alexey V. Koisevnikov, A. N. Andin
Rok vydání:	2018
Předmět:	010405 organic chemistry Stereochemistry Isatin Organic Chemistry Substituent 010402 general chemistry 01 natural sciences Biochemistry Fascaplysin Indigo 0104 chemical sciences chemistry.chemical_compound chemistry Drug Discovery Methylene Cancer cell lines
Zdroj:	Tetrahedron Letters. 59:708-711
ISSN:	0040-4039
Popis:	A simple approach towards the pyrido[1,2-a:3,4-b′]diindole system via the reaction of indigo with methylene active compounds was used for the syntheses of the marine alkaloids 6-oxofascaplysin, fascaplysin, and their derivatives. It was also demonstrated that the reaction with ketones led to indigo decomposition and the formation of isatin derivatives. The derivative of fascaplysin with a phenyl substituent at C-7 demonstrated 2–3 times greater inhibitory activity against selected cancer cell lines than fascaplysin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::26f9c4b1c527a43c3f6e26d5cfecb76c https://doi.org/10.1016/j.tetlet.2018.01.023 Zobrazit plný text záznamu Full Text from ScienceDirect