ChemInform Abstract: An α-Aminomethyl Carbanion Equivalent via a Novel Barbier Reaction: (1H-Naphtho[1,8-de]-1,2,3-triazin-2-yl)methyl Anion

Autor:	Sosale Chandrasekhar, Malayalam Sridhar
Rok vydání:	2010
Předmět:	Barbier reaction chemistry.chemical_compound chemistry Hydrogenolysis Ethanolamines Moiety Amine gas treating General Medicine Medicinal chemistry Carbanion Catalysis Triazine
Zdroj:	ChemInform. 31
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200036077
Popis:	A novel sonication-promoted Barbier reaction putatively generated the titled species from the corresponding naphthotriazinylmethyl chloride and magnesium in THF: its formal addition to a variety of carbonyl compounds in situ, occurred in excellent yields. Subsequent catalytic hydrogenolysis of the triazine moiety demasked the amine, thus defining a route to various phenylethylamines (including the alkaloid ‘mescaline’), or ethanolamines (in two cases), in excellent overall yields.
Databáze:	OpenAIRE
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