Model compounds for protein-nucleic acid interactions. 5. 5-S-Cysteinyluracil monohydrate, a photoaddition product between an amino acid and pyrimidine base

Autor:	Helen M. Berman, A. J. Varghese, Graheme J. B. Williams
Rok vydání:	1977
Předmět:	chemistry.chemical_classification Pyrimidine Stereochemistry Hydrogen bond Uracil General Chemistry Crystal structure Biochemistry Catalysis Amino acid chemistry.chemical_compound Colloid and Surface Chemistry chemistry Chemical bond Covalent bond Nucleic acid Organic chemistry
Zdroj:	Journal of the American Chemical Society. 99:3150-3154
ISSN:	1520-5126 0002-7863
DOI:	10.1021/ja00451a047
Popis:	The molecular and crystal structure of a pyrimidine-amino acid irradiation product, 5-S-cysteinyluridine, has been determined by x-ray crystallography. The cell dimensions are a = 14.59 (3) A, b = 6.82 (1) A, c = 5.05 (1) A, ..beta.. = 95.1 (1)/sup 0/, space group P2/sub 1/ with two formula units of C/sub 7/H/sub 9/N/sub 3/O/sub 4/S.H/sub 2/O per cell. The pyrimidine rings are linked together in ribbons by four hydrogen bonds. Seven other hydrogen bonds interconnect the other polar functions and indicate how the unusual conformation of the cysteinyl group is stabilized. The irradiation product in its observed conformation can be fit into a RNA helix and proposed structures of intermediates in the in vivo covalent coupling of cysteine to uracil are described.
Databáze:	OpenAIRE
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