N6 - tert -Butoxycarbonyl derivatives of sydnone imines: Preparation and synthetic use

Autor:	Alina S. Samarskaya, Valery N. Kalinin, Ilya A. Cherepanov, Ivan A. Godovikov, Konstantin A. Lyssenko, Anastasia A. Pankratova
Rok vydání:	2018
Předmět:	010405 organic chemistry Hydrochloride Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound Deprotonation chemistry Derivative (finance) Drug Discovery Electrophile Sydnone imine Protecting group Sydnone
Zdroj:	Tetrahedron Letters. 59:727-729
ISSN:	0040-4039
Popis:	A highly efficient gram-scale method for the C(4)-functionalization of sydnone imine hydrochloride derivatives was developed. This new approach was realized through consecutive reactions including the preparation of a C(3)-substituted N 6 - tert -butoxycarbonyl sydnone imine derivative, deprotonation with n -BuLi and reaction of the lithiated-intermediate with an electrophilic agent, and removal of the Boc protecting group.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::26eef5a4fa5c958f22e8c175ef09bde4 https://doi.org/10.1016/j.tetlet.2018.01.019 Zobrazit plný text záznamu Full Text from ScienceDirect