| Popis: |
Publisher Summary The use of retinal transplantation as a possible therapy for retinal degenerative diseases appears to be progressing rapidly to the human study stage. This chapter discusses number of findings critical to the progress of this field. The current retinal transplantation work encompasses a number of different strands of research that have developed independently, as well as with reference to each other, and have recently begun to integrate. The broad areas of research are sub-retinal transplants, which initially focused on reconstruction of retinal structure, but have subsequently examined functional recovery; and peripheral nerve grafts, which have studied the ability of inner retinal cells—specifically retinal ganglion cell—to regenerate functional connections with central visual structures. However, a limitation to grafting as a routine therapy lies in sourcing of cells. Freshly harvested cells present logistic problems, not only in supply of suitable donor retinae, but also in screening the cells sufficiently for infective agents. |
