Impaired Glutamatergic Neurotransmission in Migraine With Aura? Evidence by an Input-Output Curves Transcranial Magnetic Stimulation Study

Autor:	Simona Talamanca, Brigida Fierro, Filippo Brighina, Antonio Palermo, Giuseppe Cosentino, Simone Vigneri, Angela Rita Puma
Rok vydání:	2011
Předmět:	Aura medicine.medical_treatment Neurological disorder medicine.disease Migraine with aura Transcranial magnetic stimulation medicine.anatomical_structure Neurology Migraine Anesthesia medicine Ictal Neurology (clinical) Levetiracetam medicine.symptom Psychology Motor cortex medicine.drug
Zdroj:	Headache: The Journal of Head and Face Pain. 51:726-733
ISSN:	0017-8748
DOI:	10.1111/j.1526-4610.2011.01893.x
Popis:	(Headache 2011;51:726-733) Objective.— An imbalance between activity of inhibitory and facilitatory intracortical circuits could play a central role in migraine etiology. We used input–output curves to achieve further information about intracortical excitability of motor cortex in migraine with aura. Methods.— Input–output curves were measured in the right abductor pollicis brevis muscle at rest in 12 patients suffering from migraine with aura and 8 healthy subjects. Stimuli were delivered at intensity ranging from 100% to 160% of resting motor threshold with 10-second inter-stimulus intervals. Seven patients were studied before and during treatment with levetiracetam. Results.— Results showed a greater motor-evoked potential amplitude in response to increasing intensity of stimuli in patients compared to controls (P
Databáze:	OpenAIRE
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