Ameliorative Effects of Pine Bark Extract on Spermatotoxicity by α-Chlorohydrin in Rats
| Autor: | Changjong Moon, Hyung-Seon Baek, In-Chul Lee, Chun-Sik Bae, Hyoung-Chin Kim, Jong-Choon Kim, Seung-Chun Park, Sung-Hwan Kim, Sung-Ho Kim |
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| Rok vydání: | 2013 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Antioxidant biology Chemistry medicine.medical_treatment Glutathione peroxidase Glutathione Epididymis Malondialdehyde Andrology chemistry.chemical_compound medicine.anatomical_structure Biochemistry Catalase Apoptosis biology.protein medicine Peroxidase |
| Zdroj: | Phytotherapy Research. 28:451-457 |
| ISSN: | 0951-418X |
| DOI: | 10.1002/ptr.5016 |
| Popis: | We investigated the protective effects of pine bark extract (Pycnogenol®, PYC, Horphag Research Ltd., Route de Belis, France) against α-chlorohydrin (ACH)-induced spermatotoxicity in rats. Rats were orally administered ACH (30 mg/kg/day) with or without PYC (20 mg/kg/day) for 7 days. Administration of ACH significantly decreased sperm motility. α-Chlorohydrin also caused histopathological alterations and apoptotic changes in caput epididymides. An increased malondialdehyde concentration and decreased glutathione content, as well as catalase and glutathione peroxidase activities were also found. In contrast, PYC treatment significantly prevented ACH-induced spermatotoxicity, including decreased sperm motility, histopathological lesions, and apoptotic changes in the caput epididymis. Pycnogenol® also had an antioxidant benefit by decreasing malondialdehyde and increasing levels of the antioxidant glutathione and the activities of the antioxidant enzymes catalase and peroxidase in epididymal tissues. These results indicate that PYC treatment attenuated ACH-induced spermatotoxicity through antioxidant and antiapoptotic effects. Copyright © 2013 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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