Structure-Activity Relationship of Clerodane Diterpenoids Acting as Antifeedant Agents

Autor:	Carlos E. Tonn, Héctor A. Baldoni, Marta E. Sosa, E.A. Jauregui, Ricardo D. Enriz, O. S. Giordano
Rok vydání:	1994
Předmět:	chemistry.chemical_compound chemistry Stereochemistry Structure–activity relationship Biological activity General Chemistry Biology Diterpene General Agricultural and Biological Sciences Terpenoid
Zdroj:	Journal of Agricultural and Food Chemistry. 42:2958-2963
ISSN:	1520-5118 0021-8561
DOI:	10.1021/jf00048a059
Popis:	Considering the feeding-deterrent activities exhibited toward Tenebrio monitor (L.) (Coleoptera: Tenebrionidae) of several diterpenes with the clerodane skeleton isolated in our laboratory, a structure-activity relationship study was undertaken. A series of different clerodane diterpenoids was analyzed by performing an exhaustive study of their electronic and conformational behaviors. The results indicate that the antifeedant activity of these clerodane diterpenoids is mediated, at least, through two binding sites. Apparently one important factor contributing to the biological activity is a high conformational flexibility for the torsion angle of the β-furyl group
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::26e58150e1b3d8dba7fc522aa9613f9b https://doi.org/10.1021/jf00048a059 Zobrazit plný text záznamu