Wound-healing effect of electrospun gelatin nanofibres containingCentella asiaticaextract in a rat model
| Autor: | Ming-Hsien Li, Yueh-Sheng Chen, Chiung-Hua Huang, Jen-Yu Yeh, Chun-Hsu Yao |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
food.ingredient
Biomedical Engineering Medicine (miscellaneous) 02 engineering and technology Pharmacology 010402 general chemistry 01 natural sciences Gelatin Biomaterials food parasitic diseases medicine Fibroblast Centella integumentary system biology Chemistry 021001 nanoscience & nanotechnology biology.organism_classification Electrospinning 0104 chemical sciences Membrane medicine.anatomical_structure Drug delivery 0210 nano-technology Wound healing Antibacterial activity Biomedical engineering |
| Zdroj: | Journal of Tissue Engineering and Regenerative Medicine. 11:905-915 |
| ISSN: | 1932-6254 |
| Popis: | Centella asiatica (CA) is a traditional herbal medicine that has been shown to exert pharmacological effects on wound healing. This study demonstrated that CA extract facilitates the wound-repair process by promoting fibroblast proliferation and collagen synthesis and exhibits antibacterial activity. Gelatin nanofibres containing C. asiatica extract were fabricated via electrospinning and were shown to exhibit dermal wound-healing activity in a rat model. The wound areas of rat skin treated with electrospun gelatin membranes containing C. asiatica (EGC) presented the highest recovery rate compared with those treated with gauze, neat gelatin membranes and commercial wound dressings. The results of the histopathological examination support the outcome of the wound models. Contact-angle and water-retention measurements confirmed that the addition of C. asiatica extract did not significantly affect the hydrophilicity of the EGC membranes. The measured weight loss revealed that the EGC membranes are biodegradable. The findings suggest that EGC membranes are a promising material for the treatment of skin wounds. Copyright © 2015 John Wiley & Sons, Ltd. |
| Databáze: | OpenAIRE |
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