| Popis: |
Malignant obesity hypoventilation syndrome (MOHS) is a severe multisystem disease due to effects of obesity. MOHS is associated with increased healthcare utilization and a high risk of mortality. This syndrome is largely unrecognized because providers usually do not associate the patients’ multiple medical problems and obesity. Subjects with this syndrome have severe obesity-related hypoventilation along with systemic hypertension, diabetes and metabolic syndrome, left ventricular hypertrophy with diastolic dysfunction, pulmonary hypertension, and hepatic dysfunction. MOHS should be suspected in any obese patient presenting with acute respiratory failure. Management of this condition includes short-term measures (correcting the acute hypercapnia and treatment of triggers of acute decompensating episode) and long-term measures (directed toward weight loss, maintenance therapy with noninvasive ventilation, and management of comorbidities). Due to its proven benefits reversing the multiple metabolic and organ dysfunctions associated with MOHS, bariatric surgery should always be considered in this condition. |
