| Autor: |
Wei-Qiang Gao, Natasha Shinsky, Belinda Cairns, John W. Winslow, Paul Moran, Robert Gerlai, Jane Winer, Mark Armanini, H S Phillips, A. Shih, P. Williams |
| Rok vydání: |
1999 |
| Předmět: |
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| Popis: |
Publisher Summary This chapter describes application of immunoadhesins, perhaps most relevant for the behavioral neuroscientist. It focuses on a particular protein family (EphA receptor tyrosine kinases) and the investigation of their potential role in certain aspects of behavior and brain function. The chapter is intended to be an example to delineate the advantages along with the disadvantages of using immunoadhesins, a method novel in behavioral neuroscience. In addition, the present findings revealed a role for EphA receptor tyrosine kinases in cognitive function in the adult mammalian brain. These findings open an unexpected avenue into the functional analysis of this large receptor protein family and may lead to novel targets for therapeutic intervention in human brain and behavioral disorders. They also demonstrate that protein targeting with the application of immunoadhesins may be a useful research strategy in the analysis of molecular components involved in such complex behavioral traits as learning and memory. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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