Antianginal Efficacy of Sustained Release Gallopamil

Autor: Avijit Lahiri, Edward B. Raftery, Edward L. Rose
Rok vydání: 1993
Předmět:
Zdroj: Drug Investigation. 5:212-221
ISSN: 1179-1918
0114-2402
DOI: 10.1007/bf03258449
Popis: To determine whether the sustained release formulation of the calcium antagonist gallopamil has prolonged antianginal efficacy, we performed symptom-limited treadmill exercise tests using the Bruce protocol in 25 patients with chronic stable angina at trough plasma gallopamil concentrations using 4 dosages vs placebo in a double-blind forced-titration protocol. Analysis of variance showed significant improvements in exercise parameters with gallopamil 75 and 100mg twice daily. With gallopamil 100mg twice daily, exercise time increased by 1.1 minutes (p < 0.001), time to angina by 1.4 minutes (p < 0.001), and time to 1mm ST-segment depression by 1.0 minute (p < 0.01). There was no change in peak ST-segment depression at this higher workload. With gallopamil 100mg twice daily, resting and peak heart rate fell from 78 ± 2 to 74 ± 2 and 132 ± 4 to 128 ± 3 beats/minute ± SEM respectively; rate of rise of heart rate fell from 8.2 ± 0.5 to 7.0 ± 0.4 beats/minute2 ± SEM. Resting systolic blood pressure fell from 131 ± 4 to 124 ± 3mm Hg ± SEM; peak blood pressure was unchanged. Side effects were minimal. Thus, the sustained release preparation of gallopamil provides good antianginal efficacy at trough plasma concentrations and is well tolerated.
Databáze: OpenAIRE
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