Valproic acid attenuates blood pressure, vascular remodeling and modulates ET-1 expression in L-NAME induced hypertensive rats

Autor:	Boobalan Raja, Thangarasu Silambarasan, Thiyagarajan Rajeshwari, Jeganathan Manivannan
Rok vydání:	2014
Předmět:	medicine.medical_specialty Valproic Acid Antioxidant Adult male Hydrochloride medicine.medical_treatment medicine.disease_cause Endothelin 1 chemistry.chemical_compound Blood pressure Endocrinology chemistry Oral administration Internal medicine medicine Oxidative stress Food Science medicine.drug
Zdroj:	Biomedicine & Preventive Nutrition. 4:195-202
ISSN:	2210-5239
DOI:	10.1016/j.bionut.2013.09.002
Popis:	The present study was considered to assess the antihypertensive and antioxidant effect of valproic acid, against Nω- nitro-L arginine methyl ester hydrochloride (L-NAME) induced hypertension in male Wistar rats. Hypertension was prompted in adult male albino rats of the Wistar strain, weighing 180–220 g, by oral administration of the L-NAME (40 mg/kg body weight/day) in drinking water for 4 weeks. The L- NAME hypertensive rats revealed significant ( P P P P P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::26d23eec0939e42200747730d47b2cbb https://doi.org/10.1016/j.bionut.2013.09.002 Zobrazit plný text záznamu Full Text from ScienceDirect