Inducibility of Ventricular Arrhythmia 1 Year Following Treatment with Heavy Ion Irradiation in Dogs with Myocardial Infarction

Autor:	Sachie Tanaka, Sadaki Inokuchi, Mari Amino, Teruyo Tsukada, Teruhisa Tanabe, Koichiro Yoshioka, Masako Izumi, Yuji Ikari, Tadashi Hashida, Noboru Kawabe, Yoshiya Furusawa
Rok vydání:	2017
Předmět:	0301 basic medicine medicine.medical_specialty medicine.diagnostic_test Ventricular Tachyarrhythmias business.industry Stimulation General Medicine 030204 cardiovascular system & hematology medicine.disease Heavy ion irradiation Microsphere 03 medical and health sciences QRS complex 030104 developmental biology 0302 clinical medicine Internal medicine cardiovascular system Cardiology medicine Myocardial infarction Animal studies Cardiology and Cardiovascular Medicine business Electrocardiography
Zdroj:	Pacing and Clinical Electrophysiology. 40:379-390
ISSN:	0147-8389
DOI:	10.1111/pace.13031
Popis:	BACKGROUND Targeted external heavy ion irradiation (THIR) of rabbit hearts 2 weeks after myocardial infarction (MI) reduced the vulnerability of fatal ventricular tachyarrhythmias (VT/VF) in association with the increased connexin43 (Cx43). Increased Cx43 was maintained for at least 1 year in normal rabbits, but the long-term antiarrhythmic effects in the MI model are unknown. We investigated the propensity for late potentials and VT/VF inducibility. METHODS Intracoronary injection of microspheres was performed to induce nontransmural MI in anesthetized eight beagles. Four beagles were treated with THIR (12 C6+ , 15 Gy) 2 weeks later (MI + THIR group), and four without THIR served as controls (MI group). Signal-averaged electrocardiography, programmed electrical stimulation, immunohistochemical analysis, and echocardiograms were performed at 1 year. RESULTS Filtered QRS duration was exacerbated after MI and remained unchanged for 1 year in the MI group (118 ± 1.4 ms), but significantly returned toward baseline in the MI + THIR group (109 ± 6.9 ms). Similarly, root mean square voltage of the last 40 ms was exacerbated after MI, but recovered after THIR. VT/VF inducibility decreased to 25% in the MI + THIR group compared with 100% in the MI group. Immunostaining Cx43 expression in cardiac tissues significantly increased by 24-45% in the MI + THIR group. Left ventricular ejection fractions remained within the normal range in both groups. CONCLUSION A single exposure of the dog heart to 12 C irradiation attenuated vulnerability to ventricular arrhythmia after the induction of MI for at least 1 year through the modulation of Cx43 expression.
Databáze:	OpenAIRE
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