Sleep-Disordered Breathing Is Independently Associated With Increased Aggressiveness of Cutaneous Melanoma
| Autor: | Jorge Abad, Mónica González, Amaia Urrutia, Lorena Comeche, Antonio Cruz-Medina, Luis Javier del Pozo, Maria Jose Selma-Ferrer, Sonia Segura, Erika Miranda, Santiago Antonio Juarros, Francisco Campos-Rodriguez, Jaime Corral, Pilar Manchado, Esther de Eusebio, Daniela Cullen, Nuria Reyes-Nuñez, Mónica de la Peña, Teresa Gomez-Garcia, Cristian Perna, Isaac Almendros, Blanca de Unamuno, Olga Mediano, Eusebi Chiner, Miguel Ángel Martínez-García, Maider Mateos, Aida Muñoz, A. Martorell, Ferran Barbé, Bienvenido Barreiro, Jose Antonio Aramburu, Mercedes Mayos, Eva Arias, Josep M. Montserrat, David Gozal, Cristina Carrera, Valentin Cabriada, Verónica Velasco, Adam Boada, Ana Fortuño, Rosa M. Martí, Ana Mozos, Joan Dalmau, Isabel Betlloch, Ramon Farré, Felipe Aizpuru, Manuel Sánchez de la Torre, Irene Cano, Juan F. Masa, Eduardo Alcaraz, Pedro Landete, Zully Vásquez, Jose Gardeazabal, Monica Llombart, Cristina Navarro, Paula Rodriguez, Erica Riveiro-Falkenbach, N Curcó, Eduardo Nagore, Luis Hernández, Julian Caballero, Martina Alés, Raquel Catalá, M. Angeles Gonzalez, José Luis Rodríguez-Peralto, Amalia Pérez-Gil, José Bañuls, Olga Cantalejo, Manuel Moragon, Antonio Azón, María Pérez-Crespo, Cristina Martínez González, Andrea Crespo, Alberto García-Ortega, Nuria Grau, M. Fernanda Troncoso, Jesús Martín, Javier Gómez de Terreros, Alicia Sanchez de la Torre, Pablo Ortiz, María Somoza, Esther Pastor, Manuel Formigón |
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| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty business.industry Incidence (epidemiology) Melanoma Sleep apnea Cancer Critical Care and Intensive Care Medicine medicine.disease respiratory tract diseases 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Apnea–hypopnea index Interquartile range Internal medicine Cutaneous melanoma medicine Sleep study Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | Chest. 154:1348-1358 |
| ISSN: | 0012-3692 |
| DOI: | 10.1016/j.chest.2018.07.015 |
| Popis: | Background Sleep-disordered breathing (SDB) has been associated with a greater incidence and mortality of cancer, although such findings are inconsistent. However, no large studies are currently available to investigate this association in patients with a specific type of cancer. This study seeks to assess potential relationships between SDB severity and aggressiveness markers of cutaneous melanoma. Methods Four hundred and forty-three patients with a diagnosis of melanoma underwent a sleep study within 6 months of diagnosis. General demographics were collected, along with melanoma characteristics and polygraphic parameters consisting of the apnea-hypopnea index (AHI) and indices of both continuous and intermittent night-time oxyhemoglobin desaturation (DI4%). An exploration of independent relationships between SDB and various objective melanoma aggressiveness markers (Breslow index, presence of ulceration, presence of regression, mitotic index, stage of severity, damage to the sentinel lymph, and spreading of the melanoma) was performed. Results Patients in the upper tertiles of AHI or DI4% were 1.94 (95% CI, 1.14-3.32; P = .022) and 1.93 (95% CI, 1.14-3.26; P = .013) times more likely, respectively, to present with aggressive melanoma (Breslow index > 1 mm) than those in the lowest tertiles of these sleep attributes after adjustment for age, sex, tumor location, and BMI. This association was particularly prominent among patients 2 mm. The presence of the additional markers of aggressiveness was also associated with higher AHI and DI4% values. Conclusions The severity of SDB was independently associated with greater aggressiveness of cutaneous melanoma, particularly among younger patients. |
| Databáze: | OpenAIRE |
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