Ectopic Foci Study on the Crest Terminalis in 3D Computer Model of Human Atrial
| Autor: | Andrés P. Castaño, Elvio Heidenreich, Andrés Castillo, Carlos A. Ruiz-Villa |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Atrium (architecture) business.industry Gap junction Atrial fibrillation Reentry medicine.disease Nerve conduction velocity Electrophysiology Internal medicine cardiovascular system Cardiology Medicine Electrical Remodeling Crest cardiovascular diseases business Neuroscience |
| Zdroj: | Advances in Intelligent and Soft Computing ISBN: 9783642288388 PACBB |
| DOI: | 10.1007/978-3-642-28839-5_18 |
| Popis: | Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. Epidemiological studies show that AF tends to persist over time, creating electrophysiological and anatomical changes called remodeled atrial. It has been shown that these changes result in variations in conduction velocity (CV) in the atrial tissue. The changes caused by electrical remodeling in a model of action potential (AP) of atrial myocytes have been incorpotated in this study, coupled with an anatomically realistic three-dimensional model of human dilated atrium. Simulations of the spread of AP in terms of anatomical and electrical remodeling and remodeling of gap junctions were measured vulnerable windows of reentry generation on the crest terminalis of the atrium. The results obtained indicate that vulnerable window in the remodeling of gap junctions shifted 38 ms with respect to the model dilated, which shows the impact of structural remodeling Several types of permanent reentry of figures in form of eight and in form of rotor, favored by the underlying anatomy of the atrium were obtained. |
| Databáze: | OpenAIRE |
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