Co-Existence of Gametic and Agametic Seminiferous Tubules in a Chimeric Mouse

Autor:	S.M. Schmutz, S.J. Caldwell, W.C. Hagele, W.K. Latshaw, F. Hrudka
Rok vydání:	1989
Předmět:	Mesonephric tubules endocrine system medicine.medical_specialty Histology Leydig cell urogenital system Testicle Biology Epididymis Sertoli cell Sperm Cell biology medicine.anatomical_structure Seminiferous tubule Endocrinology Internal medicine medicine Anatomy Blood–testis barrier
Zdroj:	Cells Tissues Organs. 135:269-274
ISSN:	1422-6421 1422-6405
Popis:	Six chimeras, including 4 phenotypic males and 2 females, were produced by aggregation of F¶ (C57BL × BALB/c) and Swiss white embryos. All were fertile, except 1 male, whose deviation in testicular structure prompted this light- and electron-microscopic study. This chimera had a well-developed sperm-conducting system, sperm in the epididymis and active accessory sex glands.The testes displayed typical parenchymal and stromal components with the important exception of co-existence of gametic and agametic seminiferous tubules. These tubules were organized in territories of quasi-lobular configurations which appeared to open separately into rete testis.The former corresponded to normally developed and active seminiferous tubules, while the latter were solid testicular cords devoid of any germ cells and embedded in solid masses of interstitial (Leydig) cells. Special mitochondrial transformations were identified in sustentacular (Sertoli) cells of both types of tubules, in maturing spermatids and sperm. These and other submicroscopic sperm defects might be the cause of infertility.
Databáze:	OpenAIRE
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