| Popis: |
Enalaprilat is a potent and reversible inhibitor of the plasma and tissue angiotensin-converting enzyme (ACE); it is used clinically in the treatment of hypertension (Patchett et al., 1980; Gross et al., 1981). Although enalaprilat has potent and prompt therapeutic activity when administered intravenously, its high polarity and transport characteristics cause it to be poorly absorbed from the gastrointestinal tract. This leads to extremely low bioavailability of enalaprilat when administered orally (Biollaz et al., 1982). |
