Leptin administration to cold-acclimated rats reduces both food intake and brown adipose tissue thermogenesis
| Autor: | E. Rial, M. Puerta, M. Abelenda, A. Ledesma |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Food intake
medicine.medical_specialty Plasma glucose Physiology Chemistry Leptin digestive oral and skin physiology White adipose tissue Biochemistry Endocrinology medicine.anatomical_structure Internal medicine Brown adipose tissue Decreased energy Anorectic medicine General Agricultural and Biological Sciences Thermogenesis Developmental Biology |
| Zdroj: | Journal of Thermal Biology. 28:525-530 |
| ISSN: | 0306-4565 |
| DOI: | 10.1016/s0306-4565(03)00053-6 |
| Popis: | Acute (24 h) and chronic (3 weeks) cold-exposure causes an increase in energy utilization to maintain body temperature. As a result, there is a decrease in body fat, a reduced plasma leptin concentration and a concomitant hyperphagia. When cold-acclimated rats were subjected to a chronic administration of leptin, a reduction in food intake was observed. This finding demonstrates that leptin can display its satiating role even in animals with a physiological hyperphagia as that taking place in cold-exposed rats. Nevertheless, cold-acclimated leptin-treated rats did not reach a fasting-like state since their plasma glucose, free fatty acids and β -hydroxybutyrate levels were unchanged. Simultaneously, a reduction in brown adipose tissue thermogenesis took place in the cold-acclimated leptin-treated rats. These results show that in cold-acclimated rats the fall in energy gains induced by the anorectic effect of leptin is compensated by a decreased energy expenditure. |
| Databáze: | OpenAIRE |
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