The role of CD1 molecules in immune responses to infection

Autor:	Juli K. Maher, Mitchell Kronenberg
Rok vydání:	1997
Předmět:	Endosome Immunology Antigen uptake CD1 Colocalization hemic and immune systems chemical and pharmacologic phenomena Biology complex mixtures Microbiology Immune system parasitic diseases Immunology and Allergy lipids (amino acids peptides and proteins) Mannose receptor CD8 Intracellular
Zdroj:	Current Opinion in Immunology. 9:456-461
ISSN:	0952-7915
Popis:	Recent work on CD1 molecules has demonstrated that human CD1b and a lipoglycan from mycobacteria that CD1b presents colocalize to late endosomes. Presentation of this lipoglycan by CD1b requires antigen uptake via the mannose receptor. CD8 + CD1-restricted T cells can decrease the load of intracellular mycobacteria by granule release. TCR-transgenic and CD1-deficient mice have provided insights into the role of CD1 in the T helper responses required for the clearance of some microorganisms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::26b0a6fe1cd495eb4f5812580444a4e4 https://doi.org/10.1016/s0952-7915(97)80095-7 Zobrazit plný text záznamu Full Text from ScienceDirect