MSCS in Scenarios of Infection and Inflammation: Focus on Neonatal Diseases
| Autor: | B. Thébaud, M. Pierro |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Neonatal Diseases Genetic enhancement Mesenchymal stem cell Inflammation Cell Biology Biology Pathogenesis 03 medical and health sciences 030104 developmental biology Immune system Immunology Genetics medicine Progenitor cell Stem cell medicine.symptom Molecular Biology Developmental Biology |
| Zdroj: | Current Stem Cell Reports. 2:158-167 |
| ISSN: | 2198-7866 |
| DOI: | 10.1007/s40778-016-0045-5 |
| Popis: | The imbalance of inflammatory and anti-inflammatory responses in favor of inflammation plays a major role in the pathogenesis of many neonatal diseases. Inflammation in the perinatal period carries important long-term consequences, including neurodevelopmental and respiratory complications. Treatments able to restore immune homeostasis may reduce neonatal mortality and prevent long-term deleterious multi-organ consequences of unchecked inflammation. Mesenchymal stromal cells are a heterogenous group of progenitors cells with potent anti-inflammatory and immunomodulatory potential, among other diverse mechanisms of action. Thus, mesenchymal stromal cells (MSCs) may represent a novel and effective therapy for several neonatal diseases, potentially capable of preventing their long-term complications. This paper reviews the role of inflammation in the perinatal period and the therapeutic role of MSCs, focusing on their anti-inflammatory potential. |
| Databáze: | OpenAIRE |
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