Low serum folate status in the second trimester increase the risk of low birthweight in Chinese women

Autor: Chaoqun Liu, Liqian Ou, Dehao Cao, Shengzhu Huang, Zengnan Mo, Luyun Wei, Jiarong Tian, Xiaobo Yang, Xiujuan Zhu, Yu Long
Rok vydání: 2018
Předmět:
Zdroj: Journal of Obstetrics and Gynaecology Research. 44:2037-2044
ISSN: 1341-8076
DOI: 10.1111/jog.13757
Popis: AIM This study aimed to explore the influence of maternal folate and vitamin B12 (B12) status during pregnancy on the incidence of low birthweight (LBW) infants. METHODS A total of 6203 eligible women registered in seven hospitals in southern China, and 230 cases with singleton live births and 382 controls were matched for further analyses. The concentrations of serum folate and B12 were detected with chemiluminescence microparticle immunoassay on ARCHITECT i2000-1. Conditional logistic regression was used to evaluate the effects of folate and B12 levels on LBW. RESULTS Maternal serum folate levels increased basically with increasing the period of folic acid supplementation (P trend
Databáze: OpenAIRE