Membrane Protein Dislocation by the Rhomboid Pseudoprotease Dfm1: No Pore Needed?
| Autor: | Dönem Avci, Marius K. Lemberg |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Rhomboid Cell Cell Biology Endoplasmic-reticulum-associated protein degradation Biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Membrane protein Proteasome Cytoplasm medicine Biophysics Dislocation Molecular Biology 030217 neurology & neurosurgery |
| Zdroj: | Molecular Cell. 69:161-162 |
| ISSN: | 1097-2765 |
| Popis: | Defective ER-resident membrane proteins need to be ejected into the cytoplasm in order to be degraded by the proteasome, but the exact mechanism remains unclear. In this issue of Molecular Cell, Neal et al. (2018) reveal that the rhomboid pseudoprotease Dfm1 defines the central ERAD component for membrane protein dislocation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|