Pregnane glycosides from Dregea volubilis and their α-glucosidase inhibitory activity
| Autor: | Ki Sung Kang, Nguyen Thi Cuc, Phan Tuan Phuong, Nguyen Xuan Nhiem, Nguyen Thi Kim Thuy, Seung Huyn Kim, Chau Van Minh, Nguyen Thi Mai, Phan Van Kiem, Bui Huu Tai, Truong Thi Thu Hien |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Chromatography 010405 organic chemistry Chemistry Dregea volubilis Pregnane Glycoside Plant Science 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound medicine Methanol Agronomy and Crop Science α glucosidase inhibitory Biotechnology Acarbose medicine.drug |
| Zdroj: | Phytochemistry Letters. 37:90-94 |
| ISSN: | 1874-3900 |
| Popis: | Three new pregnane glycosides namely volubilosides D-F (1–3) along with three known, dregeoside Da1 (4), volubiloside A (5), and drevoluoside N (6) were isolated from the methanol extract of the leaves of Dregea volubilis using combined chromatographic methods. Their structures were elucidated by 1D-, 2D-NMR, and HR-ESI-MS spectra and comparing with those reported in the literature. Compounds 5 and 6 showed the most significant α-glucosidase inhibitory activity at the concentration of 40 μM with inhibition of 51.3 ± 3.2% and 50.4 ± 3.1%, respectively, compared to acarbose (59.8 ± 1.6%). |
| Databáze: | OpenAIRE |
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