Abstract P5-08-26: Treatment patterns for breast cancer brain metastasis
| Autor: | Jose Pablo Leone, B Haraldsson, EA Chrischilles, Bradley D. McDowell |
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| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Cancer Research. 77:P5-08 |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/1538-7445.sabcs16-p5-08-26 |
| Popis: | Background: There is sparse data on how mainstay treatments for brain metastasis (BM) are used in clinical practice and whether their usage has changed over time. Our population-based study presents the rates of surgical resection, radiation therapy, and chemotherapy in a large cohort of women with breast cancer BM. Methods: Women diagnosed with breast cancer between 1973 and 2013 were identified from the NCI linkage between the SEER program and Medicare claims data. Identification of BM was via ICD-9 diagnosis codes for secondary CNS malignancy on claims, and was defined as at least one inpatient claim and/or two or more outpatient claims. Treatment was defined as any claim filed with a procedure code for surgical resection of a BM, chemotherapy, and BM-directed radiation therapy. We excluded women without continuous Medicare coverage for a year before to 60 days after their first BM claim and women diagnosed with primary cancer other than breast cancer. Results: The proportion of women receiving treatment after BM claim increased from a low of 50.4% in 1992 to 66.8% in 2013 (p Table 1 OR; 95% CI RadiationResectionChemotherapyAge: Per 5 years0.8; 0.8-0.90.8; 0.7-0.90.8; 0.7-0.8Race: Black vs. white0.7; 0.6-0.90.6; 0.5-0.90.9; 0.8-1.2Stage: Distant vs. localized1.2; 1.0-1.40.6; 0.5-0.91.1; 0.9-1.3Comorbidities: ≥2 vs. 10.7; 0.6-0.80.6; 0.4-0.80.6; 0.5-0.8ER/PR: +/+ vs. -/-0.5; 0.4-0.50.6; 0.5-0.70.8; 0.7-0.9Lifetime BC burden: ≥2 vs. 10.9; 0.8-1.21.0; 0.8-1.41.0; 0.8-1.3SEER Registry: 2000+ vs. 1973+1.1; 0.9-1.21.2; 0.9-1.40.9; 0.7-1.0Extracranial metastasis: Y vs. N2.9; 2.5-3.40.8; 0.6-0.95.4; 3.8-7.4Year of BM: Per 5 years1.1; 1.1-1.21.0; 0.9-1.11.1; 1.0-1.2Original reason for Medicare enrollment: Disability or ESRD vs. Age0.9; 0.7-1.10.9; 0.6-1.30.6; 0.5-0.8Marital status: Married vs. not1.0; 0.9-1.11.1; 0.9-1.41.2; 1.0-1.3Interval from BC to BM: ≥1 year vs. Conclusions: We found that the proportion of women with breast cancer BM who received treatment has increased over time. Further, logistic regression revealed multiple noteworthy contrasts, including a positive relationship between care at an AMC and surgical resection, while women who received care at an AMC had lower odds of radiation or chemotherapy. Citation Format: Haraldsson B, Leone JP, McDowell BD, Chrischilles EA. Treatment patterns for breast cancer brain metastasis [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P5-08-26. |
| Databáze: | OpenAIRE |
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