Triglyceride-lowering effect of pitvastatin in a rat model of postprandial lipemia
| Autor: | Taro Tamaki, Hideo Suzuki, Masaki Kitahara, Yasunobu Yoshinaka, Fumiyasu Sato, Yasushi Saito, Hiroyuki Yamazaki, Taro Aoki |
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| Rok vydání: | 2002 |
| Předmět: |
Pharmacology
medicine.medical_specialty Triglyceride biology Atorvastatin Area under the curve Hydroxymethylglutaryl-CoA reductase Microsomal triglyceride transfer protein chemistry.chemical_compound Postprandial Endocrinology chemistry Internal medicine medicine biology.protein Pitavastatin medicine.drug Chylomicron |
| Zdroj: | European Journal of Pharmacology. 444:107-113 |
| ISSN: | 0014-2999 |
| Popis: | The triglyceride-lowering effect of pitavastatin, a potent 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, was investigated in a rat model of postprandial lipemia. Plasma triglyceride levels started to increase 4 h after the fat load, reached the maximum at 6 h and then gradually decreased. A single dose of pitavastatin (1 mg/kg) significantly suppressed chylomicron-triglyceride secretion into the lymph by 40% and delayed the elevation of plasma triglyceride. Pitavastatin at 1 mg/kg decreased the 6-h plasma triglyceride levels by 53% and at 0.5 mg/kg decreased the 0–12 h area under the curve (AUC) of triglyceride levels by 56%. Atorvastatin also caused decreases, but to a lesser extent. Pitavastatin, and atorvastatin to a lesser extent, reduced the activity of the intestinal microsomal triglyceride transfer protein (MTP) at 6 h. These results suggested that a single dose of pitavastatin lowered postprandial triglyceride levels in rats by decreasing chylomicron-triglyceride secretion, probably through a reduction of intestinal MTP activity and triglyceride droplet formation in the endoplasmic reticulum. |
| Databáze: | OpenAIRE |
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