mer-Tris(β-alaninato)cobalt(III): Crystal structure, solution properties and its DNA cleavage in the presence of ascorbic acid

Autor:	Chew Hee Ng, Han Kiat Alan Ong, Thiam Seong Chong, Wee Tee Tan, Siang Guan Teoh, Lai Peng Lim, Koh Sing Ngai
Rok vydání:	2005
Předmět:	Tris Coordination sphere Ligand Radical Inorganic chemistry chemistry.chemical_element Crystal structure Ascorbic acid Inorganic Chemistry chemistry.chemical_compound chemistry Polymer chemistry Materials Chemistry Physical and Theoretical Chemistry Cobalt TBE buffer
Zdroj:	Polyhedron. 24:1503-1509
ISSN:	0277-5387
DOI:	10.1016/j.poly.2005.03.101
Popis:	In its crystal structure, mer-tris(β-alaninato)cobalt(III), mer-[Co(β-ala)3], assumes a half-chair conformation. The complex has been additionally characterized by UV–Vis spectroscopy on its buffered solutions, electrospray ionization-mass spectroscopy (ESI-MS) and cyclic voltammetry. Its larger λmax value (visible region) compared to cobalt(III) complexes of α-amino acids suggests that β-alaninate is a weaker field ligand. Compared to CoIII hexamine complexes with six nitrogen-ligating atoms, mer-[Co(β-ala)3], with a N3O3 coordination sphere, is more easily reduced. The complex alone does not cleave DNA but can do so in the presence of ascorbic acid in TBE buffer pH 8.3. DNA cleavage can be attributed to ascorbate free radicals generated by one-electron transfer from ascorbate ions to mer-[Co(β-ala)3]. This represents the first report of DNA cleavage by a cobalt chelated amino acid complex.
Databáze:	OpenAIRE
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