The Cholinergic Binding Site: From Sequence to Function

Autor: Jonathan M. Gershoni, Rachel Mosckovitz, Ami Aronheim, Bella Ohana, Ileana Rusu, Yoav Eshel
Rok vydání: 1989
Předmět:
Zdroj: Methods in Protein Sequence Analysis ISBN: 9783642738364
DOI: 10.1007/978-3-642-73834-0_68
Popis: Whereas the sequence of the nicotinic acetylcholine receptor (AChR) has been known since 1983 (Numa et al 1983), a true understanding of how this receptor functions is far from clear. In fact, this situation is quite characteristic of much of today’s molecular biology. The purification of a given protein is readily feasible, N-terminal sequencing has been impressively perfected and the subsequent steps for cloning the desired protein and the’ generation of a postulated sequence have become almost routine. Yet strategies, which allow the efficient correlation between sequence and function, are still being developed and few have been proven effective.
Databáze: OpenAIRE