Methyldopa in breast milk and its relation to maternal plasma levels
| Autor: | Sarah B. Holliday, Denise C. Clark, John A. Hoskins, G. C. Budden |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Chromatography Ion exchange business.industry food and beverages Obstetrics and Gynecology Plasma levels Breast milk High-performance liquid chromatography fluids and secretions Endocrinology Internal medicine medicine cardiovascular diseases Free drug Methyldopa business Volume concentration Conjugate medicine.drug |
| Zdroj: | Journal of Obstetrics and Gynaecology. 3:109-111 |
| ISSN: | 1364-6893 0144-3615 |
| DOI: | 10.3109/01443618209083110 |
| Popis: | SummaryThe concentration of methyldopa in maternal plasma and milk, and of the sulphate conjugate in milk, has been measured in hypertensive mothers treated with the drug. Eight mothers gave samples which were analysed by high performance liquid chromatography using an ion exchange column and an electrocheraical detector. The total methyldopa concentration (free plus O-sulphate) in milk was less than 0·8 μg/ml in the samples studied. Generally the concentration of the O-sulphate in the milk was greater than that of the free drug; and milk levels were higher than plasma levels. The low concentrations found in breast milk do not contraindicate breast-feeding during treatment with methyldopa. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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