The efficacy of Combizym in the treatment of Chinese patients with dyspepsia: a multicenter, randomized, placebo-controlled and cross-over study
| Autor: | Shu Dong Xiao, Sheng Liang Chen, Zhi Hua Ran, Shi Yao Chen, Chun Hua Zong, Yao Zong Yuan, Xian Bao Zhan, Ping Zheng, Wei Fen Xie, Zhao Shen Li, Ji yao Wang |
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| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Journal of Digestive Diseases. 10:41-48 |
| ISSN: | 1751-2980 1751-2972 |
| DOI: | 10.1111/j.1751-2980.2008.00361.x |
| Popis: | OBJECTIVE: To evaluate the efficacy and safety of Combizym treatment in Chinese patients with dyspepsia. METHODS: In this multicenter, randomized, placebo-controlled cross-over study, a total of 151 patients (76 men and 75 women, mean age: 44.67 ± 6.46 years, range: 22–67 years) with dyspepsia whose symptoms were not relieved by placebos were recruited. They were randomly divided into group A (79 patients, 2 weeks of Combizym treatment, two tablets post-meal, t.i.d.; then 1 week of wash-out, followed by 2 weeks of placebo treatment, two tablets post-meal, t.i.d.) or group B (72 patients, 2 weeks of placebo treatment, two tablets post-meal, t.i.d. then one week of wash-out, followed by 2 weeks of Combizym treatment, 2 tablets post-meal, t.i.d.). The index of severity of the dyspepsia symptoms was evaluated before and after each treatment phase with Combizym or the placebo. RESULTS: Compared with the placebo, 2 weeks of Combizym treatment decreased the severity index of dyspepsia symptoms significantly (27.64 ± 1.77 to 9.72 ± 1.33 vs 23.99 ± 1.28 to 22.03 ± 1.40, P |
| Databáze: | OpenAIRE |
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