Effect of Enterococcus faecium SF68 on serum cobalamin and folate concentrations in healthy dogs
| Autor: | A. B. Olmedilla, B. Blanco, M. Novales, Pedro J. Ginel, Rosario Lucena |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty 040301 veterinary sciences 030106 microbiology Gastroenterology Cobalamin Inflammatory bowel disease law.invention 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound Probiotic Blood serum Serum folate law Internal medicine medicine Clinical significance Vitamin B12 Small Animals biology business.industry 04 agricultural and veterinary sciences biology.organism_classification medicine.disease chemistry business Enterococcus faecium |
| Zdroj: | Journal of Small Animal Practice. 59:438-443 |
| ISSN: | 0022-4510 |
| DOI: | 10.1111/jsap.12845 |
| Popis: | Objective To study the effect of a 14-day administration of the probiotic Enterococcus faecium SF68 on serum concentrations of cobalamin and folate in healthy dogs. Materials and methods Thirty-six healthy dogs were randomly allocated between probiotic and control groups. Enterococcus faecium SF68 was administered to the probiotic group for 14 days whereas the control group did not receive any product. A blood sample was taken from all dogs when starting the administration (day 1), when the administration ended (day 14) and 14 days later (day 28). Serum cobalamin and folate concentrations and the canine inflammatory bowel disease activity index scores were determined at each time point. Results There was a progressive reduction of mean serum cobalamin in the probiotic group during the 28-day study, with significantly lower concentration at day 28 compared to baseline and day 14 concentrations. Moderate hypocobalaminaemia was observed in eight dogs at day 28. Probiotic administration was associated with a non-significant increase in mean serum folate concentration at day 14, and a significant decrease at day 28 compared with day 1. The canine inflammatory bowel disease activity index score remained unaltered during the study. Clinical significance Short-term Enterococcus faecium SF68 administration caused a significant reduction of mean cobalamin concentration and moderate hypocobolaminaemia in eight of 18 dogs. Monitoring serum folate appears unnecessary because the probiotic caused a non-significant increase that returned to baseline values after administration was discontinued. |
| Databáze: | OpenAIRE |
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