Inhibition of T cell proliferation by human alveolar macrophages
| Autor: | J. M GRANGE, P. G HOLT, J. W UPHAM |
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| Rok vydání: | 1998 |
| Předmět: | |
| Zdroj: | Thorax. 53:437-437 |
| ISSN: | 0040-6376 |
| DOI: | 10.1136/thx.53.5.437 |
| Popis: | The demonstration by Upham et al 1that human alveolar macrophages selectively inhibit proliferation of T cells by secretion of unidentified effector molecules raises the question as to whether pathological processes in the lung characterised by extensive macrophage recruitment or activation can have a systemic effect on T cell development. It has been shown in several studies that patients with pulmonary tuberculosis who are not infected by HIV often show a lymphopenia principally affecting the CD4+ T cells.2 3 This appears to be a transient phenomenon as the CD4+ … |
| Databáze: | OpenAIRE |
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