Glucose Intolerance and Impaired Insulin Release Following 6-Hydroxydopamine Administration to Intact Rats1

Autor:	A. Jackson, W. Olson, R. Sharp, P. Felts, S. Culbert, I. M. Burr
Rok vydání:	1974
Předmět:	Hydroxydopamine medicine.medical_specialty geography geography.geographical_feature_category Chemistry Basal insulin Insulin medicine.medical_treatment Islet In vitro chemistry.chemical_compound Endocrinology In vivo Internal medicine medicine Systemic administration Oxidopamine
Zdroj:	Endocrinology. 94:1072-1076
ISSN:	1945-7170 0013-7227
Popis:	The effect of systemic administration of 6-hydroxydopamine to rats on glucose tolerance and insulin release in vivo, and insulin release in vitro, has been determined. Rats given SO mg⁄kg of 6-hydroxydopamine exhibited marked glucose intolerance 2, 4 and 6 weeks after injection. This was associated with markedly increased basal insulin levels and reduced insulin release in response to glucose in vivo at all times tested. Islets from pancreases removed from treated rats 1 month after injection exhibited diminished insulin release when tested with glucose in a perifusion system; both primary and secondary components of the biphasic insulin response to glucose were reduced in comparison with islets from untreated animals. (Endocrinology 94: 1072, 1974)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2666fa0638c6630f09cefbab747bd322 https://doi.org/10.1210/endo-94-4-1072 Zobrazit plný text záznamu