Additional file 2: Figure S2. of ALS-linked misfolded SOD1 species have divergent impacts on mitochondria

Autor: Pickles, Sarah, Semmler, Sabrina, Broom, Helen, Destroismaisons, Laurie, Legroux, Laurine, Arbour, Nathalie, Meiering, Elizabeth, Cashman, Neil, Velde, Christine Vande
Předmět:
Popis: Misfolded SOD1 antibody AMF7-63 specifically identifies mutant SOD1 in spinal cord but not liver from SOD1G93A rats. The capacity for AMF7-63 to detect misfolded SOD1 in homogenates or isolated mitochondria from spinal cords and livers was assayed by immunoprecipitation. Rabbit IgG (IgG) serves as control. Input is 10Â Îźg of homogenate or isolated mitochondria. From top to bottom bands correspond to non-specific (ns), human (hSOD1) and rat (rSOD1) SOD1. (PPTX 562Â kb)
Databáze: OpenAIRE