Interaction of Phospholipid and Antibiotic Ionophores, GramicidinA′ and Valinomycin, in Mixed Monolayers
| Autor: | Tomoyoshi Mita, Yuki Sairyo |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Chemistry
Stereochemistry Organic Chemistry Ionophore Synthetic membrane Phospholipid Biological membrane General Medicine Applied Microbiology and Biotechnology Biochemistry Thermotropic crystal Analytical Chemistry Crystallography chemistry.chemical_compound Valinomycin Monolayer Gramicidin Molecular Biology Biotechnology |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 56:1971-1975 |
| ISSN: | 1347-6947 0916-8451 |
| DOI: | 10.1271/bbb.56.1971 |
| Popis: | To obtain information concerning the effects of ionophores on biological membranes, the thermotropic behavior of ionophores such as gramicidin A′ and valinomycin in monolayers was investigated by measuring the surface pressure–area (π–A) and the surface viscosity-area (ηs–A) isotherms. Gramicidin A’ had an isotherm having the transition from a liquid-expanded through an intermediate to a condensed state, while valinomycin had a concave isotherm. The π–A isotherms for two ionophores had a decremental shift with increasing temperatures, depending upon a variety of their molecular structures. A distinct difference between the two ionophores in ηs–A isotherms was observed. In addition, the interaction of dimyristoylphosphatidylcholine (DMPC) with the two ionophores in mixed monolayers was investigated. When valinomycin was mixed with DMPC, no deviation from the additivity rule occurred below and above the phase transition temperature Tc of DMPC. However, when gramicidin A′ was mixed with DMPC, a considerable ... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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