HCC risk post-SVR with DAAs in East Asians: findings from the REAL-C cohort
| Autor: | Mayumi Maeda, Ming-Lun Yeh, Sang Bong Ahn, Dae Won Jun, Yoshiyuki Ueno, Dong Hyun Lee, Etsuko Iio, Yuichiro Eguchi, Norihiro Furusyo, Man-Fung Yuen, Akihiro Tamori, Hansen Dang, Yasuhito Tanaka, Satoshi Yasuda, Carla Pui-Mei Lam, Ramsey Cheung, Hideyuki Nomura, Mindie H. Nguyen, Grace Lai-Hung Wong, Makoto Nakamuta, Linda Henry, Jang Han Jung, Do Seon Song, Ming-Lung Yu, Cheng-Hao Tseng, Hidenori Toyoda, Chung-Feng Huang, Real-C Investigators, Hiroaki Haga, Jun Hayashi, Pei-Chien Tsai, Masaru Enomoto, Eileen L. Yoon, Eiichi Ogawa, Hirokazu Takahashi, Yao-Chun Hsu |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Cirrhosis Hepatology business.industry Incidence (epidemiology) virus diseases medicine.disease Gastroenterology digestive system diseases Colorectal surgery 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Cohort Propensity score matching medicine 030211 gastroenterology & hepatology Risk factor Liver cancer business neoplasms |
| Zdroj: | Hepatology International. 14:1023-1033 |
| ISSN: | 1936-0541 1936-0533 |
| Popis: | Despite HCV cure, patients remain at risk for HCC, but risk factor data for HCC following SVR are limited for Asian patients. To address this gap, we analyzed 5814 patients (5646 SVR, 168 non-SVR) from the Real-World Evidence from the Asia Liver Consortium for HCV (REAL-C) who did not have HCC or a history of HCC at baseline (pre-DAA treatment) and did not develop HCC within 6 months of baseline. To assess the effect of SVR on HCC incidence, we used 1:4 propensity score matching [(PSM), age, sex, baseline cirrhosis, and baseline AFP] to balance the SVR and non-SVR groups. In the PSM cohort (160 non-SVR and 612 SVR), the HCC incidence rate per 100 person years was higher in the non-SVR compared to the SVR group (5.26 vs. 1.94, p |
| Databáze: | OpenAIRE |
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