Microwave Assisted Synthesis and Antimicrobial Activity of (E)-1-{2/3/4-[(1-Aryl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-3-(2-morpholinoquinolin-3-yl)prop-2-en-1-ones
| Autor: | Vijay Kumar Pujari, Sridhar Pervaram, Srilalitha Vinnakota, Arram Ganesh, Sreedhar Maroju, Ramana Kumar Kakarla |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Sodium ascorbate
010405 organic chemistry Aryl chemistry.chemical_element General Chemistry Carbon-13 NMR 010402 general chemistry Antimicrobial 01 natural sciences Medicinal chemistry Copper Microwave assisted 0104 chemical sciences chemistry.chemical_compound chemistry Click chemistry Mass spectrum |
| Zdroj: | Russian Journal of General Chemistry. 88:1502-1507 |
| ISSN: | 1608-3350 1070-3632 |
| DOI: | 10.1134/s1070363218070241 |
| Popis: | A novel series of (E)-1-{2/3/4-[(1-aryl-1H-1,2,3-triazol-4-yl)methoxy]phenyl}-3-(2-morpholinoquinolin-3-yl)prop-2-en-1-ones is synthesised from terminal alkynes with aromatic azides by the Click reaction in the presence of copper sulphate and sodium ascorbate in DMF: water under microwave irradiation. All the synthesised compounds are characterised by IR, 1H and 13C NMR, and mass spectra, and tested in vitro for antimicrobial activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|