Comparative Effect of Aspirin, Meloxicam and Terminalia catappa Leaf Extract on Serum Levels of Some Inflammatory Markers in Alloxan Induced Diabetic Rats
| Autor: | Daniel U. Owu, Asuquo E. Asuquo, Ezekiel E. Ben |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Aspirin
biology business.industry Insulin medicine.medical_treatment C-reactive protein Inflammation General Medicine Pharmacology medicine.disease Meloxicam chemistry.chemical_compound chemistry Alloxan Diabetes mellitus medicine biology.protein medicine.symptom Interleukin 6 business medicine.drug |
| Zdroj: | Asian Journal of Research in Biochemistry. :1-10 |
| ISSN: | 2582-0516 |
| DOI: | 10.9734/ajrb/2019/v4i130058 |
| Popis: | Background: The association between diabetes mellitus and inflammation is established but the use of non-steroidal anti-inflammatory drugs is not without some health risk. Aim: The study was aimed at comparing the levels of some inflammatory biomarkers in diabetic rats treated with aqueous leaf extract of Terminalia catappa, non steroidal anti-inflammatory drugs (NSAIDs) and exogenous insulin. Materials and Methods: Thirty six (36) Wistar rats were assigned to 6 groups of 6 animals each. Group 1 and 2 served as normal and diabetic controls and received orally 5ml/kg body weight of distilled water. Group 3 was diabetic treated orally with 130mg/kg body weight of aqueous leaf extract of Terminalia catappa. And groups 4, 5 and 6 were administered orally with aspirin (30mg/kg), meloxicam (2mg/kg) and 0.75U/kg body weight of insulin subcutaneously. Diabetes was induced with intraperitoneal injection of 150mg/kg body weight of alloxan solution and diabetes confirmed after 72 hours with blood glucose levels ≥200mg/dl. The experiment lasted for 14 days and blood was collected by cardiac puncture for serum analysis of C-reactive protein, Interleukin-6 and Fibrinogen by ELISA method. Results: The results showed significant (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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