Determination of Jasminoidin in Rabbit Plasma for the Pharmacokinetic Investigation after Single Dose Oral Administration of Gardenia jasminoides Ellis and Gardenia jasminoides Ellis Coupling Coptis chinensis Franch Extracts

Autor:	Ye-Fei Nan, Chaoni Xiao, Hong-fei Wang, Lu-sha Wei, Xinfeng Zhao, Xiaohui Zheng
Rok vydání:	2010
Předmět:	Chromatography biology Chemistry Electrospray ionization Organic Chemistry Clinical Biochemistry Coptis chinensis Gardenia jasminoides biology.organism_classification Mass spectrometry Tandem mass spectrometry Biochemistry Analytical Chemistry Pharmacokinetics Gardenia Oral administration
Zdroj:	Chromatographia. 71:1031-1037
ISSN:	1612-1112 0009-5893
Popis:	A simple, sensitive and rapid method for the analysis of jasminoidin in rabbit plasma by liquid chromatography coupled to tandem mass spectrometry was developed. Detection was by positive ion electrospray ionization in multiple reactions monitoring mode. The method included a chromatographic run of 5.0 min using a C18 analytical column and the calibration curve was linear over the concentration range of 0.5–2,000 ng mL−1 with a correlation coefficient R of 0.998 or better. The intra- and inter-day precision ranged from 3.4 to 5.6% and 4.3 to 8.2%. The intra- and inter-day assay accuracy was between −7.4 and 8.6%. The method was successfully applied for the pharmacokinetic study on jasminoidin in rabbit after a single dose oral administration of Gardenia jasminoides Ellis (Gardenia) and Gardenia coupling Coptis chinensis Franch (Coptidis) extracts.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::264eba12fad85d20725e98df78909715 https://doi.org/10.1365/s10337-010-1572-3 Zobrazit plný text záznamu Full text from SpringerLink