Designing C-Fe-O bonded MIL-88B(Fe)/jasmine petal-derived-carbon composite biosensor for the simultaneous detection of dopamine and uric acid
Autor: | Huaju Sun, Yaseen Muhammad, Zuqiang Huang, Syed Jalil Shah, Jiaxing Wang, Wenting He, Qu Zhen, Zhu Gao, Jialing Li, Zhongxing Zhao, Jinghao Fu |
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Rok vydání: | 2021 |
Předmět: |
Detection limit
Analyte Chemistry General Chemical Engineering Composite number 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Redox Industrial and Manufacturing Engineering 0104 chemical sciences Catalysis Adsorption Environmental Chemistry Cyclic voltammetry 0210 nano-technology Biosensor Nuclear chemistry |
Zdroj: | Chemical Engineering Journal. 404:126570 |
ISSN: | 1385-8947 |
Popis: | C-Fe-O bonded MIL-88B(Fe)/carbon composite was designed to enhance the sensitivity and resolution for the simultaneous detection of dopamine (DA) and uric acid (UA) based on the “adsorption enhancement and distinguished potential regulation” strategy. Fe loaded Jasmine petal derived biocarbon (Fe-JPBC) was implanted in MIL-88B(Fe) through C-Fe-O bonding, resulting in a novel composite biosensor (MIL(Fe)/Fe-JPBC). MIL-88B(Fe) exhibited improved analyte capture ability via adsorption enhancement, which significantly enhanced signal sensitivity and lowered the limit of detection (LOD). In addition, the enhanced signal transmission capacity for DA and UA was attributed to the strong interface between MOF and Fe-JPBC via C-Fe-O bond. Interestingly, the presence of this unique interface showed different catalytic properties for the redox reaction of DA and UA, and broadened the oxidation potential discrepancy between them. The MIL(Fe)/Fe-JPBC biosensor therefore exhibited well-resolved potential peaks of 240 mV for DA and UA with respective LOD of 42.0 nM and 5.6 nM. Cyclic voltammetry, adsorption kinetics and molecular simulation results revealed that compared to DA, the utilization of MIL(Fe)/Fe-JPBC to detect UA was a reaction-controlled process with higher affinity and faster adsorption rate, leading to its much lower LOD than DA. MIL(Fe)/Fe-JPBC also exhibited high anti-interference and reproducibility in the detection of simulated and real serum samples. The novel strategy of adsorption enhancement and distinguished potential regulation via C-Fe-O bond for designing composite biosensors with significantly increased sensitivity and resolution for the simultaneous detection of DA and UA could be deemed of great potential on large applications. |
Databáze: | OpenAIRE |
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