An unusual 1(10→19)abeo steroid from a jellyfish-derived fungus
| Autor: | Xiaoyi Wei, Jian Lin Li, Jee H. Jung, Yonghong Liu, Jongki Hong, Won Duk Yoon, Hyung Sik Kim, Eun La Kim |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Jellyfish
biology 010405 organic chemistry Chemistry Stereochemistry medicine.medical_treatment Organic Chemistry Absolute configuration Fungus biology.organism_classification Ring (chemistry) 01 natural sciences Biochemistry Sterol 0104 chemical sciences Steroid 010404 medicinal & biomolecular chemistry biology.animal Drug Discovery Side chain medicine Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Tetrahedron Letters. 57:2803-2806 |
| ISSN: | 0040-4039 |
| Popis: | A structurally unique C25 steroid (phomarol) was isolated from a cultured fungus (Phoma sp.) derived from the giant jellyfish Nemopilema nomurai. Its planar structure and relative configuration were established by analyzing 1D and 2D NMR data, and its absolute configuration was determined using the modified Mosher’s method and ECD calculation. Phomarol is unique with a 7-membered carbocyclic A ring [1(10 → 19)abeo], an aromatic B ring, and a side chain cyclized to form a fused pentacyclic skeleton. |
| Databáze: | OpenAIRE |
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