Vancomycin Induced Neutropenia Associated with Fever: A Case Report
| Autor: | Adila Shaukat, Muna Al Maslamani, Sumaira Rafiqui |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Side effect business.industry 030106 microbiology Clindamycin biochemical phenomena metabolism and nutrition Neutropenia medicine.disease_cause medicine.disease Discontinuation Vancomycin therapy 03 medical and health sciences 0302 clinical medicine Staphylococcus aureus Internal medicine medicine Vancomycin 030212 general & internal medicine Adverse effect business medicine.drug |
| Zdroj: | Journal of Infectious Diseases and Therapy. |
| ISSN: | 2332-0877 |
| DOI: | 10.4172/2332-0877.1000336 |
| Popis: | Vancomycin-induced neutropenia is an uncommon but potentially serious side effect of prolonged vancomycin therapy. We present a case of a 19 year old male with disseminated methicillin-resistant Staphylococcus aureus (MRSA) Infection who was treated with IV vancomycin and developed fever and neutropenia. After discontinuation of IV vancomycin and substitution with clindamycin, both fever and neutropenia resolved within 72 h. Diagnosis of vancomycin-induced neutropenia and fever was considered as there was no alternative cause of this. In addition, quick resolution of fever and neutropenia upon removal of causative drug further supported the diagnosis. Since vancomycin is widely used in clinical practice, this adverse effect should be monitored carefully. Many studies report immune mediated mechanism to be the cause of this adverse effect. However, further studies need to be done in this regard to establish the exact mechanism. |
| Databáze: | OpenAIRE |
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