Caenorhabditis elegans as a Model System for Parkinson’s Disease

Autor:	Ralf Baumeister, Mark Seifert, Enrico Schmidt
Rok vydání:	2007
Předmět:	Parkinson's disease biology Dopaminergic Neurodegeneration Model system Disease biology.organism_classification medicine.disease_cause medicine.disease Neurology medicine Identification (biology) Neurology (clinical) Neuroscience Caenorhabditis elegans Oxidative stress
Zdroj:	Neurodegenerative Diseases. 4:199-217
ISSN:	1660-2862 1660-2854
DOI:	10.1159/000101845
Popis:	Parkinson’s disease (PD) is one of the most common age-related neurodegenerative diseases that is characterized by selective loss of dopaminergic neurons. Despite recent findings from mammalian model systems, molecular mechanisms of the pathophysiology are poorly understood. Given the high conservation of molecular pathways from invertebrates to mammalians, combined with technical advantages, such as high-throughput approaches, Caenorhabditis elegans represents a powerful system for the identification of factors involved in neurodegeneration. In this review we describe that C. elegans can be used to advance our understanding of the genetic mechanisms implicated in these disorders.
Databáze:	OpenAIRE
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