(Hydroxyethyl) sulfonamide HIV-1 Protease inhibitors: Identification of the 2-methylbenzoyl moiety at P-2
| Autor: | Geralyn P. Kocan, Heintz Robert M, Getman Daniel P, Deborah E. Bertenshaw, Mischke Brent, Christine Funckes-Shippy, Lisa W. Blystone, Martin L. Bryant, Nandini Kishore, Pramod P. Mehta, Kathyrn A. Houseman, John N. Freskos |
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| Rok vydání: | 1996 |
| Předmět: |
chemistry.chemical_classification
Protease biology Chemistry Isostere Stereochemistry medicine.medical_treatment Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Sulfonamide stomatognathic system HIV-1 protease Drug Discovery medicine biology.protein Molecular Medicine Moiety Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 6:445-450 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/0960-894x(96)00035-2 |
| Popis: | We have discovered a potent low molecular weight series of HIV-1 Protease inhibitors incorporating the (R)-(hydroxyethyl) sulfonamide isostere. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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