Determination of elemental impurities of Arsenic, Cadmium, Mercury, Lead and Palladium content in Testosterone propionate by using ICP-MS
| Autor: | P. Suresh, Konda Ravi Kumar |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
inorganic chemicals
Testosterone propionate Cadmium 010401 analytical chemistry chemistry.chemical_element 01 natural sciences 0104 chemical sciences Mercury (element) 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Impurity Elemental analysis 030220 oncology & carcinogenesis Inductively coupled plasma mass spectrometry Arsenic Palladium Nuclear chemistry |
| Zdroj: | Asian Journal of Research in Chemistry. :195-202 |
| ISSN: | 0974-4150 0974-4169 |
| DOI: | 10.52711/0974-4150.2021.00035 |
| Popis: | The aim of the present work is to develop and establish a validated analytical method for the determination of arsenic, cadmium, mercury, lead and palladium content in testosterone propionate by using inductive coupled plasma mass spectroscopy (ICP-MS). Samples were analyzed after a preparation of sample solution by dissolving in suitable solvents of concentrated nitric acid and concentrated hydrochloric acid. In the present method, RF power of 1550 watts, RF matching is 1.80 V, nebulizer flow of 0.10 rps and plasma view at spectrum mode were used. Octopole conditions are He flow is on, He flow rate is 4.3 mL/min and energy discrimination is 3.0 V were used. Significant savings in sample volumes, reagents, analysis cost and time are realized. Arsenic, cadmium, mercury, lead and palladium are primary concerned due to their high toxicity and potential contaminants should be limited in testosterone propionate and the developed method was validated according to ICH and USP guidelines. The correlation coefficient, recovery rate, LOD and LOQ reached the acceptable limits. The validated method was selective, sensitive, rapid and capable of the determination of elemental impurities of arsenic, cadmium, mercury, lead and palladium content in bulk drugs. |
| Databáze: | OpenAIRE |
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