Caffeine citrate effects on gastrointestinal permeability, bacterial translocation and biochemical parameters in newborn rats after long-term oral administration
| Autor: | Foufa Bouabsa, Aicha Tir Touil, Mazhar Salim Al Zoubi, Nadia Chelli, André Leke, Boumediene Meddah |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Mediterranean Journal of Nutrition and Metabolism. 15:307-321 |
| ISSN: | 1973-7998 1973-798X |
| Popis: | BACKGROUND: Caffeine is a potent central and respiratory acting agent used in neonatology to treat apnea in premature newborns. OBJECTIVE: This study investigates the effects of caffeine orally administered to newborn rats on gastrointestinal permeability, bacterial translocation and different biochemical parameters. METHODS: Newborn rats were divided into different groups (N = 06). The treated newborn rats were orally administered with standard caffeine doses (12 mg/kg per day), and the control groups received a placebo. The animals were weighed daily until sacrifice. Blood samples, mesenteric lymph nodes (MLN) and organs were aseptically collected. Furthermore, different biochemical (D-Lactate) and oxidative stress biomarkers (MDA, CAT, SOD and GSH) were examined. Microbiological analyses were performed to assess microbiota alterations and bacterial translocation. RESULTS: Preliminary results showed that caffeine administration decreased the level of bacterial translocation over time. The treatment reduced plasma D-lactate levels (p |
| Databáze: | OpenAIRE |
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