Comparison of hematological parameters in congenital hypothyroidism in neonates: A case controls study
| Autor: | A T Arasar Seeralar, S Shyama, S Subramaniam, C R Subhasree |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
endocrine system
Pediatrics medicine.medical_specialty 030219 obstetrics & reproductive medicine endocrine system diseases medicine.diagnostic_test business.industry Anemia Thyroid Retrospective cohort study medicine.disease Congenital hypothyroidism 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Obstetrics and gynaecology medicine Euthyroid 030212 general & internal medicine Sample collection business Mean corpuscular volume |
| Zdroj: | Indian Journal of Obstetrics and Gynecology Research. 7:590-594 |
| ISSN: | 2394-2754 2394-2746 |
| DOI: | 10.18231/j.ijogr.2020.125 |
| Popis: | Background: Thyroid hormones play an important role in human metabolism. Red blood cells abnormalities are mostly associated with thyroid hormones. However, they are very rarely investigated and associated to the permanent and transient congenital hypothyroidism in Tamil Nadu’s Government Territory care centre in Chennai. In this study, an attempt was made to study the haematological status in permanent and transient hypothyroidism neonates at birth. Materials and Methods: This retrospective study included 135 subjects, among which were permanent hypothyroidism (n=9), transient hypothyroidism (n=18), and euthyroid neonates (108). This study was carried out at department of biochemistry, Regenix super speciality laboratories and sample collection were done at Government Institute of Child’s health and hospital for children and Government institute of obstetrics and Gynaecology and hospital for Women under Madras Medical college, Chennai. The haematological parameters and thyroid profile of the subjects were assessed by sysmex heamatology analyser, Roche Cobas e411 ECLIA and Neonatal screening by BIORAD QUANTASE ELISA. Mean and standard deviation, analysis of variance (two way anova) with p Results: In this study group, we compared the homological status in these groups, permanent, transient, and euthyroid as controls neonates. We found that haematological status like Hb, RBC, MCV, and RDW were significantly increased at birth in both permanent and transient hypothyroidism were compared with euthyroid neonates, results are significant. The results reported in these are Mean ± S.D., were statistically tested by ANOVA. In permanent Congenital Hypothyroidism (CH), MCV (79.97-87.58 fl) and RDW (13.98-16.6%), whereas in Transient Congenital Hypothyroidism, MCV (72.52-87.05 fl) and RDW(13.41- 15.68%), and controls MCV (78.69-82.12 fl) and RDW(12.4 – 14.3%), suggesting that these patients were at risk of anemia and other RBS abnormalities. Mean corpuscular volume is a |
| Databáze: | OpenAIRE |
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