| Autor: | Valentino J. Stella, William H. Streng, Erika A. Zannou |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Chromatography Osmotic concentration Cyclodextrin Chemistry Vapor pressure osmometry Organic Chemistry Pharmaceutical Science Dosage form Freezing point Inclusion compound chemistry.chemical_compound Molecular Medicine Osmotic pressure Pharmacology (medical) Solubility Biotechnology |
| Zdroj: | Pharmaceutical Research. 18:1226-1231 |
| ISSN: | 0724-8741 |
| DOI: | 10.1023/a:1010947631380 |
| Popis: | Purpose. The purpose of this study was to determine the osmolality of sulfobutylether (SBE) and hydroxypropyl (HP) derivatives of cyclodextrins (CDs) via vapor pressure osmometry (VPO) and freezing point depression (FPD). (SBE) and HP-CDs are efficient excipients capable of solubilizing and stabilizing poorly water-soluble drugs in parenteral formulations. (SBE)-CDs have also been used as solubility enhancers and osmotic agents for the sustained release of poorly water-soluble drugs from osmotic pump tablets. The knowledge of the CD's osmolality in solution or inside such tablets would allow one to further characterize the release mechanisms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink