Grapefruit juice enhance the uptake of coenzyme Q10 in the human intestinal cell-line Caco-2

Autor:	Masaki Kobayashi, Akiko Ochiai, Ken Iseki, Takeshi Hirano, Shirou Itagaki, Mitsuru Sugawara
Rok vydání:	2010
Předmět:	Coenzyme Q10 food.ingredient biology Chemistry General Medicine Absorption (skin) Pharmacology Grapefruit juice Intestinal absorption Analytical Chemistry Bioavailability chemistry.chemical_compound food Caco-2 biology.protein Efflux Food Science P-glycoprotein
Zdroj:	Food Chemistry. 120:552-555
ISSN:	0308-8146
DOI:	10.1016/j.foodchem.2009.10.052
Popis:	Coenzyme Q10 (CoQ10) is very widely consumed by humans as a food supplement. However, CoQ10 is taken up from the intestine into the circulation at a low rate. The absorption of compounds from the gastrointestinal tract is one of the important determinants for oral bioavailability. Secretory transport limits the oral bioavailability of compounds. It has been reported that efflux transport of CoQ10 is mediated by P-glycoprotein (P-gp) in Caco-2 cells. We tried to improve intestinal absorption of CoQ10 by modulating P-gp. Since grapefruit juice (GFJ) is reported to inhibit P-gp function, we investigated the effect of GFJ on the transport of CoQ10 by Caco-2 cells. In the presence of GFJ, the basal-to-apical transport of CoQ10 was decreased and the uptake of CoQ10 was increased. These findings suggest that the combined administration of CoQ10 and GFJ could enhance CoQ10 absorption.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::260b9a4f9db119daee42d7ce16a7e147 https://doi.org/10.1016/j.foodchem.2009.10.052 Zobrazit plný text záznamu Full Text from ScienceDirect