Enantioselective synthesis of C3 substituted benzofuroindolines via catalytic asymmetric [3 + 2] cyclization of 3-substituted indoles with p-benzoquinones

Autor:	Zhen-yu Lu, Wei-qiao Lan, Xiao-Mei Zhang, Li-hua Liao, Fang-yi Liu, Jun-yi Wang
Rok vydání:	2021
Předmět:	010405 organic chemistry Chemistry Organic Chemistry P-Benzoquinones Enantioselective synthesis 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Yield (chemistry) Drug Discovery Organic chemistry Phosphoric acid
Zdroj:	Tetrahedron Letters. 76:153233
ISSN:	0040-4039
Popis:	An efficient catalytic asymmetric [3 + 2] cyclization of 3-substituted indoles with p-benzoquinones has been realized using a binol-chiral phosphoric acid. A large variety of C3 substituted benzofuroindolines compounds were achieved in moderate to high yields (up to 91% yield) and excellent enantioselectivities (up to 94% ee).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::25f5c8d4c97bcd6a7337781790ce0e86 https://doi.org/10.1016/j.tetlet.2021.153233 Zobrazit plný text záznamu Full Text from ScienceDirect